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Lei Yuan Selected Research

asperphenamate

2/2022ASPER-29 suppresses the metastasis of pancreatic cancer cells by dual inhibition of cathepsin-L and cathepsin-S.
1/2019Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells.
12/2018Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells.
8/2012JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells.

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Lei Yuan Research Topics

Disease

40Neoplasms (Cancer)
02/2022 - 06/2012
13Breast Neoplasms (Breast Cancer)
10/2021 - 06/2012
9Neoplasm Metastasis (Metastasis)
02/2022 - 12/2018
8Infections
01/2020 - 01/2016
7Inflammation (Inflammations)
01/2022 - 05/2009
6Hypoxia (Hypoxemia)
08/2022 - 05/2009
5Ovarian Neoplasms (Ovarian Cancer)
01/2022 - 04/2015
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
02/2021 - 04/2016
5Carcinoma (Carcinomatosis)
12/2019 - 06/2012
4Endometriosis
05/2022 - 11/2008
4Pancreatic Neoplasms (Pancreatic Cancer)
02/2022 - 01/2015
4Pain (Aches)
11/2021 - 07/2013
4Uterine Cervical Neoplasms (Cancer of the Cervix)
01/2020 - 01/2016
3Glioma (Gliomas)
07/2022 - 12/2019
3Dysmenorrhea (Menstrual Pain)
05/2022 - 01/2008
3Lymphatic Metastasis
01/2022 - 01/2016
3Scoliosis
11/2021 - 05/2021
3Hepatocellular Carcinoma (Hepatoma)
03/2021 - 01/2018
3Necrosis
07/2020 - 04/2016
3Body Weight (Weight, Body)
10/2019 - 05/2015
3Lymphoma (Lymphomas)
06/2019 - 07/2011
3Neuralgia (Stump Neuralgia)
01/2019 - 01/2014
3Leukemia
01/2019 - 06/2016
3Graft vs Host Disease (Graft-Versus-Host Disease)
10/2018 - 07/2011
2Immune System Diseases (Immune Disorders)
05/2022 - 07/2020
2Obesity
01/2022 - 07/2014
2B-Cell Lymphoma (Lymphoma, B Cell)
02/2021 - 10/2014
2Hematologic Neoplasms (Hematological Malignancy)
02/2021 - 02/2021
2Prostatic Neoplasms (Prostate Cancer)
04/2020 - 01/2019
2Pregnancy Complications
02/2020 - 05/2019
2Candidiasis (Moniliasis)
01/2020 - 01/2018
2Fibrosis (Cirrhosis)
01/2020 - 10/2017
2Hypersensitivity (Allergy)
01/2020 - 07/2014
2Virus Diseases (Viral Diseases)
01/2020 - 12/2016
2Urinary Bladder Neoplasms (Bladder Cancer)
12/2019 - 12/2019
2Adenocarcinoma
01/2019 - 08/2014
2Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2019 - 06/2016
2Colorectal Neoplasms (Colorectal Cancer)
03/2018 - 01/2018
2Prostatitis
05/2017 - 08/2013
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2016 - 01/2014
2Atrial Fibrillation
10/2015 - 02/2015
2Atrophy
05/2015 - 05/2009
2Ureteral Calculi
03/2015 - 06/2014
2Lung Neoplasms (Lung Cancer)
10/2014 - 08/2002
2Brugada Syndrome
04/2014 - 01/2014

Drug/Important Bio-Agent (IBA)

15Proteins (Proteins, Gene)FDA Link
02/2021 - 06/2012
7Biological ProductsIBA
07/2022 - 06/2012
7Biomarkers (Surrogate Marker)IBA
02/2021 - 11/2008
6CytokinesIBA
08/2022 - 05/2009
5Small Interfering RNA (siRNA)IBA
01/2020 - 05/2009
4NF-kappa B (NF-kB)IBA
08/2022 - 11/2008
4Pharmaceutical PreparationsIBA
05/2022 - 01/2018
4CathepsinsIBA
02/2022 - 12/2018
4asperphenamateIBA
02/2022 - 08/2012
4RNA (Ribonucleic Acid)IBA
01/2022 - 05/2009
4Chimeric Antigen ReceptorsIBA
02/2021 - 12/2015
4Long Noncoding RNAIBA
01/2021 - 11/2018
3Transcription Factors (Transcription Factor)IBA
02/2022 - 05/2009
3Cathepsin LIBA
02/2022 - 01/2020
3Messenger RNA (mRNA)IBA
07/2020 - 12/2015
3AntigensIBA
01/2019 - 06/2016
3LigandsIBA
01/2019 - 12/2016
3Cadherins (E-Cadherin)IBA
04/2017 - 10/2015
3Sodium Channels (Sodium Channel)IBA
06/2015 - 04/2014
2Immunologic Factors (Immunomodulators)IBA
05/2022 - 07/2020
2Gonadotropin-Releasing Hormone (GnRH)FDA Link
05/2022 - 07/2013
2Glucose (Dextrose)FDA LinkGeneric
03/2022 - 01/2020
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
02/2022 - 03/2018
24-boronic acid benzophenoneIBA
02/2022 - 08/2012
2cathepsin SIBA
02/2022 - 12/2018
2Cisplatin (Platino)FDA LinkGeneric
01/2022 - 01/2020
2Programmed Cell Death 1 ReceptorIBA
01/2022 - 03/2018
2Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2020 - 12/2016
2Particulate MatterIBA
02/2020 - 05/2019
2Antifungal AgentsIBA
01/2020 - 01/2018
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 12/2016
2MicroRNAs (MicroRNA)IBA
12/2019 - 01/2019
2Proteasome Endopeptidase Complex (Proteasome)IBA
01/2018 - 05/2015
2Digoxin (Digitek)FDA LinkGeneric
04/2017 - 12/2015
2Anti-Bacterial Agents (Antibiotics)IBA
03/2016 - 08/2013
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016 - 04/2015
2Doxorubicin (Adriamycin)FDA LinkGeneric
12/2015 - 10/2014
2ErbB Receptors (EGF Receptor)IBA
12/2015 - 04/2014
2PhosphoproteinsIBA
10/2015 - 09/2014
2ezrinIBA
10/2015 - 09/2014
2radixinIBA
10/2015 - 09/2014
2moesinIBA
10/2015 - 09/2014
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2015 - 05/2009

Therapy/Procedure

23Therapeutics
05/2022 - 08/2013
11Hematopoietic Stem Cell Transplantation
01/2019 - 07/2011
7Drug Therapy (Chemotherapy)
01/2022 - 09/2015
6Immunotherapy
02/2022 - 12/2015
4Spinal Fusion (Spondylosyndesis)
11/2021 - 01/2021
3Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2021 - 05/2017
2Aftercare (After-Treatment)
01/2020 - 05/2017
2Transplantation
10/2018 - 04/2015
2Hysterectomy
01/2018 - 09/2014
2Chemoradiotherapy
01/2018 - 01/2016
2Solid-State Lasers
03/2015 - 06/2014
2Lithotripsy (Extracorporeal Shockwave Lithotripsy)
03/2015 - 06/2014